Granulocyte colony-stimulating factor (G-CSF) induced disseminated erythema with CD68 positive histiocytes.

Sir, Granulocyte colony-stimulating factor (G-CSF) is used in the haematological treatment of neutropenia following cytotoxic chemotherapy and haematological disorders; it encourages proliferation and diŒerentiation of granulocytes. G-CSF therapy is occasionally known to be associated with skin rash, including neutrophilic dermatosis (1), widespread folliculitis (2) and cutaneous vasculitis (3), associated with neutrophil in® ltration in the skin. We describe a patient with a cutaneous reaction who had received G-CSF treatment for myelodysplastic syndrome. In our case, numerous CD68-positive mononuclear cells were seen in® ltrating the lesional skin.